Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 19/20 | 0.52 |
| ▸ | CYBB | P04839 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302562 | 0.89 | NOX4 (0.67) | NOX4CYBBMEN1NPC1POLB | |
| SCHEMBL1303470 | 0.87 | NOX4 (0.63) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL8481410 | 0.87 | NOX4 (0.53) | NOX4CYBBKDM4EMEN1NPC1 | |
| SCHEMBL1302115 | 0.84 | NOX4 (0.66) | NOX4CYBBKDM4EMEN1NPC1 | |
| SCHEMBL1302062 | 0.78 | NOX4 (0.63) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1302200 | 0.78 | NOX4 (0.74) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1303426 | 0.77 | NOX4 (0.70) | NOX4CYBBKDM4EMEN1NPC1 | |
| SCHEMBL17171582 | 0.74 | NOX4 (0.48) | NOX4CYBBKDM4EMEN1NPC1 | |
| SCHEMBL1303897 | 0.73 | NOX4 (0.52) | NOX4CYBBCYP3A4NOX1 | |
| SCHEMBL1302585 | 0.73 | NOX4 (0.70) | NOX4CYBBMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |