Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 14/20 | 0.75 |
| ▸ | CYBB | P04839 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1303426 | 0.91 | NOX4 (0.70) | NOX4CYBBNPC1RAB9AL3MBTL1 | |
| SCHEMBL1303175 | 0.86 | NOX4 (1.00) | NOX4CYBBNPC1RAB9AL3MBTL1 | |
| SCHEMBL2219544 | 0.83 | NOX4 (0.72) | NOX4CYBBNPC1RAB9AL3MBTL1 | |
| SCHEMBL1302232 | 0.82 | NOX4 (0.68) | NOX4CYBBMPL | |
| SCHEMBL2219961 | 0.82 | NOX4 (0.60) | NOX4CYBBUSP2 | |
| SCHEMBL1302246 | 0.80 | NOX4 (0.62) | NOX4CYBBMEN1KMT2AMPL | |
| SCHEMBL2220922 | 0.79 | NOX4 (0.56) | NOX4CYBB | |
| SCHEMBL2218143 | 0.78 | NOX4 (0.55) | NOX4CYBB | |
| SCHEMBL3615946 | 0.78 | NOX4 (1.00) | NOX4CYBBNPC1RAB9AL3MBTL1 | |
| SCHEMBL3618610 | 0.78 | NOX4 (0.77) | NOX4CYBBNPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |