Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.48 |
| ▸ | NOX4 | Q9NPH5 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYBB | P04839 | 1/20 | 0.41 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.41 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1302503 | 0.86 | NOX4 (0.40) | PGRNOX4ALDH1A1APOBEC3GCYBB | |
| SCHEMBL1302878 | 0.82 | NOX4 (0.47) | NOX4ALDH1A1KDM4ETSHRMEN1 | |
| SCHEMBL19956759 | 0.82 | NOX4 (0.41) | PGRNOX4MAPT | |
| SCHEMBL1302859 | 0.80 | PDE4B (0.48) | NOX4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL1302627 | 0.80 | MAPT (0.43) | NOX4ALDH1A1POLBKDM4EHSD17B10 | |
| SCHEMBL1303236 | 0.79 | NOX4 (0.43) | NOX4TSHRMEN1KMT2AMAPT | |
| SCHEMBL1303049 | 0.79 | PDE4B (0.46) | NOX4ALDH1A1CYBBNOX5NOX1 | |
| SCHEMBL1303159 | 0.78 | NOX4 (0.52) | NOX4CYP1A2CYP2C9CYP3A4KMT2A | |
| SCHEMBL2218229 | 0.75 | NOX4 (0.49) | PGRNOX4ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL2218729 | 0.74 | NOX4 (0.42) | NOX4ALDH1A1CYP1A2CYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860179-B1 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors | GENKYOTEX SUISSE SA (CH) | 2018-03-14 | — | — | EP | disclosed |