⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16313205 | 0.67 | — | — | |
| SCHEMBL2952280 | 0.66 | — | — | |
| SCHEMBL17883359 | 0.58 | KMT2A (0.48) | — | |
| SCHEMBL19957928 | 0.58 | KDM4E (0.31) | — | |
| SCHEMBL14305978 | 0.56 | PDE10A (0.30) | — | |
| Formamide SCHEMBL23636189 | 0.55 | ALDH1A1 (0.33) | — | |
| SCHEMBL23776431 | 0.55 | — | — | |
| SCHEMBL24163402 | 0.55 | — | — | |
| SCHEMBL13031184 | 0.53 | ALDH1A1 (0.33) | — | |
| SCHEMBL5896671 | 0.53 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |