Sugi Predict

Sugi Predict / Compounds / SCHEMBL19957522

SCHEMBL19957522

SCHEMBL19957522

CC(Oc1cccc2cccnc12)C(=O)NCCCN1CCc2ccccc2C1

nearest known ligand 0.74

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 17/20 0.74
▸ WDR77 Q9BQA1 11/20 0.74
▸ HTR7 P34969 1/20 0.53
▸ KDM4E B2RXH2 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ POLB P06746 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19957639 1.00 PRMT5 (0.74) PRMT5WDR77HTR7KDM4EALDH1A1
SCHEMBL21299846 0.94 PRMT5 (0.72) PRMT5WDR77HTR7KDM4EALDH1A1
SCHEMBL21299845 0.94 PRMT5 (0.72) PRMT5WDR77HTR7KDM4EALDH1A1
SCHEMBL19957590 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15825034 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15824852 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15825038 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935374 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL15935376 0.85 PRMT5 (1.00) PRMT5WDR77
SCHEMBL19957640 0.84 PRMT5 (0.71) PRMT5WDR77HTR7KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935243-B1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF EPIZYME INC (US) 2018-03-14 — — EP disclosed