Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 17/20 | 0.71 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15818387 | 0.93 | PRMT5 (0.69) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL19957718 | 0.87 | PRMT5 (0.73) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL19957533 | 0.86 | PRMT5 (0.74) | PRMT5WDR77 | |
| SCHEMBL19957639 | 0.84 | PRMT5 (0.74) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL19957522 | 0.84 | PRMT5 (0.74) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL15824141 | 0.83 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL15824137 | 0.83 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL15825310 | 0.83 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL17300992 | 0.83 | PRMT5 (0.82) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL17300993 | 0.82 | PRMT5 (0.81) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |