Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830272 | 0.83 | HCRTR1 (0.33) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL18672961 | 0.81 | HCRTR1 (0.32) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL15834048 | 0.81 | NOS3 (0.36) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL14349223 | 0.76 | HRH3 (0.50) | HRH4HCRTR1HCRTR2MAPK13MAPK12 | |
| SCHEMBL20889910 | 0.75 | POLB (0.50) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL19171118 | 0.72 | IDH1 (0.38) | HRH4HCRTR1HCRTR2 | |
| SCHEMBL20890615 | 0.69 | PROKR1 (0.36) | HRH4ITGB2ICAM1ITGAL | |
| SCHEMBL12530261 | 0.69 | EED (0.37) | — | |
| SCHEMBL19501405 | 0.67 | HSP90AA1 (0.38) | — | |
| SCHEMBL19501382 | 0.67 | BCHE (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |