Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | FABP6 | P51161 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830043 | 0.86 | NPY5R (0.50) | MAPTPTPN1TSHRIDO1ALDH1A1 | |
| SCHEMBL23251072 | 0.82 | KMT2A (0.49) | MAPTPTPN1TSHRIDO1ALDH1A1 | |
| SCHEMBL19633397 | 0.82 | FABP6 (0.50) | MAPTPTPN1TSHRIDO1ALDH1A1 | |
| SCHEMBL18466035 | 0.82 | KDM4E (0.53) | MAPTPTPN1TSHRIDO1ALDH1A1 | |
| SCHEMBL15829972 | 0.78 | NPY5R (0.46) | MAPTTSHRALDH1A1CCR6KMT2A | |
| SCHEMBL15829422 | 0.78 | NPY5R (0.46) | MAPTTSHRALDH1A1CCR6KMT2A | |
| SCHEMBL15830310 | 0.78 | NPY5R (0.46) | MAPTTSHRALDH1A1CCR6KMT2A | |
| SCHEMBL28306630 | 0.76 | IDO1 (0.53) | MAPTIDO1CCR6KDM1AFABP6 | |
| SCHEMBL15829995 | 0.76 | ALDH1A1 (0.61) | MAPTIDO1ALDH1A1CCR6KDM1A | |
| SCHEMBL18466173 | 0.75 | KDM4E (0.48) | MAPTPTPN1TSHRALDH1A1CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |