Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.65 |
| ▸ | WDR77 | Q9BQA1 | 17/20 | 0.65 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957750 | 1.00 | PRMT5 (0.65) | PRMT5WDR77CARM1LMNAHTT | |
| SCHEMBL19957838 | 0.91 | PRMT5 (0.61) | PRMT5WDR77CARM1 | |
| SCHEMBL19957660 | 0.81 | CARM1 (0.69) | PRMT5WDR77CARM1 | |
| SCHEMBL19957812 | 0.79 | PRMT5 (0.63) | PRMT5WDR77CARM1 | |
| SCHEMBL15825326 | 0.79 | PRMT5 (0.79) | PRMT5WDR77 | |
| SCHEMBL15935456 | 0.79 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL21384871 | 0.78 | CARM1 (0.67) | PRMT5WDR77CARM1 | |
| SCHEMBL21384872 | 0.78 | CARM1 (0.67) | PRMT5WDR77CARM1 | |
| SCHEMBL30019323 | 0.77 | CARM1 (0.74) | PRMT5WDR77CARM1LMNAHTT | |
| SCHEMBL15935367 | 0.77 | PRMT5 (1.00) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |