Sugi Predict

Sugi Predict / Compounds / SCHEMBL19959253

SCHEMBL19959253

SCHEMBL19959253

CC(C)(C)OC(=O)N1CCc2c(N)nc(Cl)nc2C1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADORA1 P30542 2/20 0.48
▸ PARP1 P09874 1/20 0.46
▸ TNKS2 Q9H2K2 1/20 0.46
▸ PARP2 Q9UGN5 1/20 0.46
▸ NR1H2 P55055 1/20 0.45
▸ ESR2 Q92731 1/20 0.43
▸ MAPT P10636 3/20 0.42
▸ KDM4E B2RXH2 1/20 0.42
▸ F12 P00748 3/20 0.41
▸ MTOR P42345 1/20 0.40
▸ MKNK1 Q9BUB5 2/20 0.39
▸ MAP4K4 O95819 1/20 0.37
▸ POLB P06746 1/20 0.36
▸ C5AR1 P21730 1/20 0.36
▸ P2RX3 P56373 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30338938 1.00 ADORA1 (0.48) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL1832511 0.87 PARP1 (0.47) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL31536045 0.86 PARP1 (0.47) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL24535151 0.84 PARP1 (0.45) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL25574315 0.83 PARP1 (0.47) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL31246448 0.83 PARP1 (0.45) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL31246476 0.83 PARP1 (0.47) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL3225674 0.81 PARP1 (0.43) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL31246480 0.80 PARP1 (0.43) ADORA1PARP1TNKS2PARP2NR1H2
SCHEMBL29057189 0.80 P2RX7 (0.39) ADORA1C5AR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2024-02-29 — — US disclosed
US-20230373999-A1 KRAS G12C INHIBITORS MIRATI THERAPEUTICS INC (US) 2023-11-23 — — US disclosed
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI), INC. (CN) 2023-02-23 — — US disclosed
WO-2021239117-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS CULLGEN (SHANGHAI) , INC. (CN) 2021-12-02 — — WO disclosed
US-20180072723-A1 KRAS G12C INHIBITORS Mirati Therapeutics, Inc. 2018-03-15 — — US disclosed
US-20180072723-A1 KRAS G12C INHIBITORS Mirati Therapeutics, Inc. 2018-03-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240066136-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 ADORA1 3590/4885PARP1 43/4885TNKS2 1034/4885
US-20180072723-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS ADORA1 4289/4885PARP1 1128/4885TNKS2 1404/4885
US-20230057177-A1 MODIFIED PROTEINS AND PROTEIN DEGRADERS DDB1, DCLRE1A, MDM2 ADORA1 3590/4885PARP1 43/4885TNKS2 1034/4885
US-20230373999-A1 KRAS G12C INHIBITORS KRAS, NRAS, HRAS ADORA1 4289/4885PARP1 1128/4885TNKS2 1404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.