Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327709 | 0.71 | AKT1 (0.57) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL29034616 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL12802064 | 0.69 | TDP1 (0.52) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL585998 | 0.69 | PARP1 (0.59) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL29923066 | 0.69 | PARP1 (0.59) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL16952628 | 0.69 | TDP1 (0.52) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL8081217 | 0.69 | PARP1 (0.48) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| SCHEMBL29589199 | 0.68 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBPARP1MEN1KMT2A | |
| M-Xylene SCHEMBL30345558 | 0.68 | TP53 (0.56) | SMN1; SMN2POLBPARP1TP53TDP1 | |
| SCHEMBL24710508 | 0.67 | TDP1 (0.50) | SMN1; SMN2POLBPARP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049296-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |