Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960809 | 0.89 | PRMT5 (0.42) | PRMT5WDR77HDAC8HDAC3HDAC1 | |
| SCHEMBL19960810 | 0.82 | PRMT5 (0.43) | PRMT5WDR77HDAC8HDAC3HDAC1 | |
| SCHEMBL11472266 | 0.65 | GRIN1 (0.50) | PRCPHDAC8HDAC3HDAC1NCOR2 | |
| SCHEMBL21400673 | 0.64 | PRMT5 (0.67) | PRMT5WDR77 | |
| SCHEMBL21236148 | 0.62 | PRCP (0.50) | PRMT5WDR77PRCPHDAC8HDAC3 | |
| SCHEMBL12489589 | 0.62 | PRCP (0.50) | PRMT5WDR77PRCPHDAC8HDAC3 | |
| SCHEMBL4239790 | 0.60 | PRCP (0.60) | PRCPHDAC8HDAC3HDAC1NCOR2 | |
| SCHEMBL15100399 | 0.60 | PRCP (0.56) | PRCPHDAC8HDAC3HDAC1NCOR2 | |
| SCHEMBL19960827 | 0.60 | ANPEP (0.40) | — | |
| SCHEMBL1077266 | 0.60 | PPARG (0.49) | HDAC8HDAC3HDAC1NCOR2HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |