Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 6/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960689 | 0.89 | PRMT5 (0.40) | PRMT5WDR77HDAC8HDAC1HDAC3 | |
| SCHEMBL19960810 | 0.87 | PRMT5 (0.43) | PRMT5WDR77HDAC8HDAC1HDAC3 | |
| SCHEMBL11472266 | 0.78 | GRIN1 (0.50) | HDAC8HDAC1HDAC3NCOR2HDAC2 | |
| SCHEMBL19960713 | 0.72 | ACE (0.43) | HDAC8HDAC1HDAC3NCOR2HDAC2 | |
| SCHEMBL6960867 | 0.70 | PARP1 (0.36) | — | |
| SCHEMBL6974370 | 0.69 | XIAP (0.35) | — | |
| SCHEMBL6970691 | 0.68 | KDM4E (0.32) | HDAC8HDAC1F2RL1 | |
| SCHEMBL6957978 | 0.68 | SIRT1 (0.41) | — | |
| SCHEMBL6966047 | 0.68 | ESR1 (0.37) | HDAC8HDAC1HDAC3NCOR2HDAC2 | |
| SCHEMBL23721558 | 0.67 | KMT2A (0.41) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |