Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.74 |
| ▸ | CA12 | O43570 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA9 | Q16790 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | IDE | P14735 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | PLCD1 | P51178 | 1/20 | 0.60 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.57 |
| ▸ | HLCS | P50747 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18025829 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL5841368 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL13169001 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL8407567 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL19069314 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL24750115 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL31621058 | 0.94 | TDP1 (0.76) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL18779801 | 0.94 | TDP1 (0.78) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL8333056 | 0.92 | TDP1 (0.73) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL288457 | 0.91 | TDP1 (0.74) | TDP1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048928-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |