Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 6/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | STS | P08842 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | CA1 | P00915 | 2/20 | 0.64 |
| ▸ | CA2 | P00918 | 2/20 | 0.64 |
| ▸ | CA9 | Q16790 | 2/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11303367 | 1.00 | ESR1 (0.77) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL6856667 | 1.00 | ESR1 (0.77) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL11743425 | 0.89 | ESR1 (0.71) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL14035876 | 0.89 | ESR1 (0.71) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| Promestriene SCHEMBL5188890 | 0.87 | ESR1 (0.61) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL12449418 | 0.87 | ESR1 (1.00) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL5168738 | 0.87 | STS (0.85) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL2232043 | 0.87 | ESR1 (1.00) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| Promestriene SCHEMBL31613772 | 0.87 | ESR1 (0.61) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 | |
| Promestriene SCHEMBL518228 | 0.87 | ESR1 (0.61) | ESR1LMNAHSD17B10MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071316-A1 | Compositions And Methods For Treating Dementia | HOFFMAN STEVEN (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071316-A1 | Compositions And Methods For Treating Dementia | PSEN2, PSEN1, CHAT | ESR1 3252/4885LMNA 445/4885HSD17B10 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.