Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.72 |
| ▸ | MMP2 | P08253 | 10/20 | 0.72 |
| ▸ | MMP9 | P14780 | 10/20 | 0.72 |
| ▸ | EGFR | P00533 | 8/20 | 0.72 |
| ▸ | MAOA | P21397 | 2/20 | 0.69 |
| ▸ | MAOB | P27338 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.66 |
| ▸ | TOP2A | P11388 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996366 | 1.00 | MMP1 (0.72) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL8751517 | 0.86 | EGFR (0.68) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL8751516 | 0.86 | EGFR (0.68) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL29258328 | 0.86 | MAPT (0.58) | MMP1MMP2MMP9EGFRRAB9A | |
| SCHEMBL29258330 | 0.86 | MAPT (0.58) | MMP1MMP2MMP9EGFRRAB9A | |
| SCHEMBL11590995 | 0.86 | EGFR (0.92) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL10160203 | 0.85 | HDAC3 (0.70) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL12555382 | 0.85 | MEN1 (0.72) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL6013376 | 0.84 | EGFR (0.77) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL2848898 | 0.84 | EGFR (0.77) | MMP1MMP2MMP9EGFRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2021-04-29 | — | — | US | disclosed |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2019-06-27 | — | — | US | disclosed |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H LEE MOFFITT CANCER CT & RES (US) | 2017-07-20 | — | — | US | disclosed |
| US-9604923-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | H.LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-11-06 | — | — | US | disclosed |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2011-08-18 | — | — | US | disclosed |
| US-7960434-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-06-14 | — | — | US | disclosed |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
| WO-2007136858-A2 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202795-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-20210121427-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-20140329900-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, JAK2 | MMP1 417/4885MMP2 2197/4885MMP9 1332/4885 |
| US-20190192461-A1 | SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-10226439-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
| US-10806712-B2 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | MMP1 520/4885MMP2 1985/4885MMP9 1476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.