Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | CDC25B | P30305 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953780 | 0.83 | RPS6KB1 (0.53) | SIRT2HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4004912 | 0.80 | MAPT (0.48) | ATRKMT2AMEN1TP53 | |
| SCHEMBL15998541 | 0.76 | HDAC1 (0.71) | SIRT2HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL7151866 | 0.74 | KMT2A (0.73) | SIRT2HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8940247 | 0.74 | KCNK3 (0.72) | SIRT2HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13335918 | 0.72 | KMT2A (0.67) | SIRT2DNMT1DNMT3AHDAC1HDAC2 | |
| SCHEMBL15238338 | 0.72 | LMNA (0.62) | HDAC1HDAC2HDAC8HDAC6ATR | |
| SCHEMBL8374911 | 0.71 | HDAC1 (0.85) | HDAC1HDAC2HDAC8HDAC6KMT2A | |
| SCHEMBL4560198 | 0.70 | KDM4E (0.65) | HDAC1HDAC2HDAC8HDAC6ATR | |
| SCHEMBL3827286 | 0.70 | HDAC1 (0.72) | HDAC1HDAC2HDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |