Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.34 |
| ▸ | NEK2 | P51955 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.33 |
| ▸ | TUBB | P07437 | 3/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21156141 | 0.87 | TSHR (0.40) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21157295 | 0.82 | EED (0.48) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL19964964 | 0.79 | EED (0.47) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL19964635 | 0.78 | EED (0.67) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL19964981 | 0.78 | TSHR (0.40) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21157286 | 0.72 | EED (0.46) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL19964915 | 0.71 | EED (0.56) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21156564 | 0.71 | EED (0.51) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21113458 | 0.70 | EED (0.62) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL19964966 | 0.69 | EED (0.45) | EEDRBBP4SUZ12EZH2AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524602-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018045971-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发有限公司 | 2018-03-15 | — | — | WO | disclosed |