Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 2/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19964981 | 0.91 | TSHR (0.40) | TSHRHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL19964983 | 0.87 | EED (0.38) | HSD17B10ALDH1A1HPGDKDM4EFNTA | |
| SCHEMBL19964980 | 0.82 | EED (0.43) | TSHRHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL21113241 | 0.76 | EED (0.42) | TSHRHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL19964635 | 0.76 | EED (0.67) | EEDRBBP4SUZ12EZH2AEBP2 | |
| SCHEMBL21113194 | 0.74 | EED (0.55) | TSHRALDH1A1HPGDKDM4EEED | |
| SCHEMBL21113354 | 0.73 | EED (0.60) | TSHRHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL21157286 | 0.72 | EED (0.46) | TSHREEDRBBP4SUZ12EZH2 | |
| SCHEMBL19964838 | 0.71 | ERN1 (0.39) | TSHRHSD17B10ALDH1A1KDM4EFNTA | |
| SCHEMBL21157356 | 0.71 | MAPT (0.44) | HSD17B10ALDH1A1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. (CN) | 2021-04-06 | — | — | US | disclosed |
| EP-3524602-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | HAIHE BIOPHARMA CO. LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968215-B2 | Pyrido five-element aromatic ring compound, preparation method therefor and use thereof | EZH2, IKZF2, SUZ12 | TSHR 3084/4885HSD17B10 3720/4885ALDH1A1 2816/4885 |
| US-20190211010-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | EZH2, IKZF2, SUZ12 | TSHR 3084/4885HSD17B10 3720/4885ALDH1A1 2816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.