Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
| ▸ | SKP1 | P63208 | 1/20 | 0.43 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18823266 | 0.80 | POLB (0.48) | MEN1KMT2APOLBCKS1BSKP1 | |
| SCHEMBL31173930 | 0.80 | POLB (0.48) | MEN1KMT2APOLBCKS1BSKP1 | |
| SCHEMBL26029492 | 0.76 | NR1H2 (0.53) | MEN1KMT2APOLBCKS1BSKP1 | |
| SCHEMBL30478271 | 0.76 | POLB (0.49) | MEN1KMT2APOLBPARP1MAPT | |
| SCHEMBL25738732 | 0.76 | POLB (0.49) | MEN1KMT2APOLBPARP1MAPT | |
| SCHEMBL12833233 | 0.75 | POLB (0.75) | MEN1KMT2APOLBPARP1GPR119 | |
| SCHEMBL29268414 | 0.75 | KMT2A (0.58) | MEN1KMT2APOLBMAPTGPR119 | |
| SCHEMBL3068899 | 0.75 | KMT2A (1.00) | MEN1KMT2APOLBLMNAHDAC4 | |
| SCHEMBL29405584 | 0.74 | HSP90AA1 (0.40) | MEN1KMT2ATP53LMNASPR | |
| SCHEMBL19968019 | 0.74 | HSP90AA1 (0.40) | MEN1KMT2ATP53LMNASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018045956-A1 | BENZIMIDAZOLE COMPOUND KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-03-15 | — | — | WO | disclosed |