Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405584 | 1.00 | HSP90AA1 (0.40) | HSP90AA1THRBHPGDUSP2RAB9A | |
| SCHEMBL22650459 | 0.75 | GSK3B (0.36) | SPRTRPV4 | |
| SCHEMBL440559 | 0.75 | HSP90AA1 (0.42) | HSP90AA1THRBSMN1; SMN2LMNATRPV4 | |
| SCHEMBL19968008 | 0.74 | MEN1 (0.59) | TP53SPRLMNAMEN1KMT2A | |
| SCHEMBL28731677 | 0.72 | PDE10A (0.35) | HPGDMEN1KMT2ATRPV4ALDH1A1 | |
| SCHEMBL20150154 | 0.71 | GABRP (0.57) | HPGDUSP2HTTLMNATSHR | |
| SCHEMBL1929985 | 0.70 | HTT (0.70) | HPGDHTTKMT2AALDH1A1CYP3A4 | |
| SCHEMBL12410963 | 0.70 | SMN1; SMN2 (0.54) | RAB9AMDM2SMN1; SMN2LMNAMEN1 | |
| SCHEMBL403869 | 0.70 | GABRP (0.46) | RAB9ASMN1; SMN2ALOX15MEN1KMT2A | |
| SCHEMBL30996511 | 0.70 | SMN1; SMN2 (0.54) | RAB9AMDM2SMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120040446-A | CDK inhibitors | 基因泰克公司 | 2025-05-27 | — | — | CN | disclosed |
| US-20220296595-A1 | CDK INHIBITORS | GENENTECH, INC. | 2022-09-22 | — | — | US | disclosed |
| CN-112225724-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-114364675-A | CDK inhibitors | 上海齐鲁锐格医药研发有限公司 | 2022-04-15 | — | — | CN | disclosed |
| EP-3966213-A1 | CDK INHIBITORS | Qilu Regor Therapeutics Inc. (CN) | 2022-03-16 | — | — | EP | disclosed |
| CN-112250669-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-02-25 | — | — | CN | disclosed |
| CN-112250669-A | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-112225724-A | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2021-01-15 | — | — | CN | disclosed |
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |
| CN-109963842-B | Benzimidazole compound kinase inhibitor and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-109963842-A | Benzimidazoles compound kinase inhibitor and its preparation method and application | 江苏豪森药业集团有限公司 | 2019-07-02 | — | — | CN | disclosed |
| WO-2018045956-A1 | BENZIMIDAZOLE COMPOUND KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 江苏豪森药业集团有限公司 | 2018-03-15 | — | — | WO | disclosed |
| CN-107793399-A | CDK4/6 inhibitor and its preparation method and application | 上海翰森生物医药科技有限公司 | 2018-03-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220296595-A1 | CDK INHIBITORS | CDKL1, CDK9, CDK6 | HSP90AA1 3152/4885THRB 3558/4885HPGD 2238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.