Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 6/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19968882 | 0.88 | SCN1A (0.37) | SCN1ASCN8AEPHX2CYP2C9C5AR1 | |
| SCHEMBL23770778 | 0.85 | SCN9A (0.37) | SCN1ASCN8ASCN9ATP53 | |
| SCHEMBL29464543 | 0.85 | SCN1A (0.34) | SCN1ASCN8AEPHX2CYP2C9KDM4E | |
| SCHEMBL19925432 | 0.85 | SCN1A (0.34) | SCN1ASCN8AEPHX2CYP2C9KDM4E | |
| SCHEMBL22323499 | 0.84 | S1PR1 (0.38) | SCN1ASCN8AEPHX2CYP2C9HSD11B1 | |
| SCHEMBL19968878 | 0.83 | SCN1A (0.38) | SCN1ASCN8ASCN9AMAPTHSD11B1 | |
| SCHEMBL19968873 | 0.81 | SCN9A (0.36) | SCN1ASCN8ASCN9AKDM4EPOLB | |
| SCHEMBL19968816 | 0.81 | SCN9A (0.36) | SCN1ASCN8ASCN9AKDM4EPOLB | |
| SCHEMBL19968874 | 0.81 | GAA (0.36) | SCN1ASCN8AEPHX2CYP2C9SCN9A | |
| SCHEMBL22323219 | 0.80 | IDH1 (0.39) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072673-A1 | N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072673-A1 | N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease | CFTR, P2RY1, P2RX5 | SCN1A 32/4885SCN8A 450/4885EPHX2 1697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.