P2RX5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13587994	0.51	3/20
SCHEMBL4629408	0.49	3/20
SCHEMBL4629412	0.43	3/20
SCHEMBL5287746	1.00	2/20
SCHEMBL7196930	1.00	2/20
SCHEMBL7196945	1.00	2/20
SCHEMBL13624677	1.00	2/20
SCHEMBL15866621	1.00	2/20
Isoppads (SCHEMBL14702227)	0.86	2/20
SCHEMBL16450980	0.79	2/20
SCHEMBL15354624	0.76	2/20
SCHEMBL5592363	0.75	2/20
SCHEMBL14506106	0.75	2/20
SCHEMBL13210908	0.73	2/20
SCHEMBL16450978	0.73	2/20
SCHEMBL14506104	0.72	2/20
SCHEMBL7196936	0.69	2/20
SCHEMBL14096001	0.65	2/20
SCHEMBL13453593	0.61	2/20
SCHEMBL14688057	0.59	2/20

Clinical trials — most relevant to P2RX5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of Methylnaltrexone on the PK/PD Profiles of Ticagrelor in Patients Treated With Morphine	PHASE4	COMPLETED
H2 Haplotype and CYP3As Polymorphisms and the Antiplatelet Response to Clopidogrel	PHASE4	COMPLETED
Add-on Cangrelor in STEMI-triggered Cardiac Arrest	PHASE4	UNKNOWN
Ticagrelor And PrEconditioning in Patients With coronaRy Artery diSease	PHASE2/PHASE3	COMPLETED
Botulinum Toxin Injections for Oral Neuropathic Pain	PHASE3	COMPLETED
Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks	PHASE3	WITHDRAWN
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Study to Assess the Tolerability of a Single Dose of Gefapixant (AF-219/MK-7264) in Subjects With Idiopathic Pulmonary Fibrosis (IPF)	PHASE2	COMPLETED
First Time in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and the Effect of Food of Single Assending Doses of GSK1482160.	PHASE1	COMPLETED
A Multiple-Dose Escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetic of HS-10383	PHASE1	UNKNOWN
A Safety Study Of A Single Vaginal Administration Of P2G12 Antibody In Healthy Female Subjects	PHASE1	COMPLETED
Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults	EARLY_PHASE1	COMPLETED
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients	nan	RECRUITING
Functional Magnetic Resonance Imaging of ATP Cough in Chronic Cough Patients	nan	COMPLETED
The Real-world Treatment Satisfaction by Gefapixiant in RCC	nan	RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)	nan	COMPLETED
Suppressive Functions of Regulatory T Cells in Migraine	nan	NOT_YET_RECRUITING
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients	nan	COMPLETED
In Vitro Studies on Pharmacological Regulation and Genetic Risk Factors of Peripheral Human Nociceptors	nan	COMPLETED
ATP and P2X3 Receptor in Chronic Cough	nan	UNKNOWN
Local Injection of Botulinium Toxin-A in Children With Dysfunctional Voiding or Refractory Nocturnal Eneuresis	nan	RECRUITING
The Role of Urinary ATP in the Diagnosis, Treatment, and Follow-up of Children With Overactive Bladder	nan	COMPLETED
Cytokines in Papillon-Lefèvre Syndrome	nan	COMPLETED
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy	nan	ENROLLING_BY_INVITATION
Developing a Method to Objectively Measure Opioid Analgesia	nan	ACTIVE_NOT_RECRUITING
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
BIOmarkers and PLAtelet Function Assessment in Myocardial Ischemia and Non Obstructive Coronary Arteries Study	nan	RECRUITING
Multisensory Stimulation on Postoperative Pain, Physiological Parameters and Fear in Children	nan	UNKNOWN
Visceral Afferents	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a P2RX5 binder may also engage these)

Protein	Name	Similarity
P51579	—	1.000	P51579 →
Q91VE2	—	1.000	Q91VE2 →
O54803	—	0.998	O54803 →
P51578	—	0.996	P51578 →
P2RX3	P2X purinoceptor 3	0.995	landscape →
Q64663	—	0.994	Q64663 →
Q3UR32	—	0.994	Q3UR32 →
Q9Z1M0	—	0.993	Q9Z1M0 →
Q5E9U1	—	0.993	Q5E9U1 →
P51577	—	0.993	P51577 →
P49654	—	0.991	P49654 →
P2RX7	P2X purinoceptor 7	0.990	landscape →
F8W463	—	0.990	F8W463 →
P2RX6	P2X purinoceptor 6	0.990	landscape →
Q99ME6	—	0.990	Q99ME6 →
P2RX1	P2X purinoceptor 1	0.989	landscape →
Q9JJX6	—	0.989	Q9JJX6 →
Q202B1	—	0.988	Q202B1 →
P47824	—	0.987	P47824 →
A7MB71	—	0.987	A7MB71 →
Q9BDK6	—	0.987	Q9BDK6 →
P2RX4	P2X purinoceptor 4	0.987	landscape →
Q9UN42	—	0.987	Q9UN42 →
Q2KJC3	—	0.985	Q2KJC3 →
Q3T0C6	—	0.985	Q3T0C6 →
Q2T9P5	—	0.985	Q2T9P5 →
P18597	—	0.985	P18597 →
Q6IFT6	—	0.984	Q6IFT6 →
Q9GLC3	—	0.984	Q9GLC3 →
P51576	—	0.984	P51576 →