Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | DRD5 | P21918 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29051117 | 0.89 | RAB9A (0.49) | ATMNPC1RAB9ADRD2CCR1 | |
| SCHEMBL29051099 | 0.89 | RAB9A (0.49) | ATMNPC1RAB9ADRD2CCR1 | |
| SCHEMBL29051096 | 0.89 | RAB9A (0.49) | ATMNPC1RAB9ADRD2CCR1 | |
| Hydrochloric Acid SCHEMBL30467162 | 0.88 | RAB9A (0.48) | ATMNPC1RAB9ADRD2CCR1 | |
| Hydrochloric Acid SCHEMBL30467173 | 0.88 | RAB9A (0.48) | ATMNPC1RAB9ADRD2CCR1 | |
| SCHEMBL3710421 | 0.82 | SLC18A3 (0.52) | DRD2SIGMAR1ALDH1A1GRIN2B | |
| SCHEMBL16994794 | 0.81 | SLC18A3 (0.49) | NPC1RAB9ADRD2DRD3TLR8 | |
| SCHEMBL21285985 | 0.81 | SLC18A3 (0.49) | DRD2DRD1DRD5ADRA2AADRA1B | |
| SCHEMBL28818445 | 0.81 | ESR2 (0.55) | — | |
| SCHEMBL28809060 | 0.81 | RAB9A (0.48) | ATMNPC1RAB9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468961-B1 | 5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2020-06-10 | — | — | EP | disclosed |
| EP-2927214-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2018-03-21 | — | — | EP | disclosed |
| CN-104995173-A | Nitrogen-containing heterocyclic compound | KYOWA HAKKO KIRIN CO LTD | 2015-10-21 | — | — | CN | disclosed |
| CN-101878217-B | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO LTD | 2014-01-15 | — | — | CN | disclosed |
| CN-101878217-A | Agent for prevention and/or treatment of skin diseases | KYOWA HAKKO KIRIN CO LTD | 2010-11-03 | — | — | CN | disclosed |