Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | HTR1F | P30939 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | TNF | P01375 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618757 | 0.92 | PDE4A (0.39) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626645 | 0.90 | HTR6 (0.41) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626414 | 0.89 | HTR6 (0.39) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626633 | 0.88 | HTR6 (0.38) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626635 | 0.88 | HTR6 (0.38) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626621 | 0.85 | HTR6 (0.44) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL16618605 | 0.84 | PRMT5 (0.36) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626639 | 0.81 | PDE4A (0.38) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL16626410 | 0.81 | NAMPT (0.36) | HTR6PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL17971587 | 0.79 | HTR6 (0.34) | HTR6PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | claimed |