Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 8/20 | 0.37 |
| ▸ | PPARD | Q03181 | 5/20 | 0.37 |
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490136 | 0.79 | BTK (0.46) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL2493885 | 0.79 | BTK (0.46) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL3268106 | 0.74 | BTK (0.45) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL3268115 | 0.74 | BTK (0.45) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL9984552 | 0.70 | BTK (0.44) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL2491729 | 0.67 | BTK (0.51) | BTKCHRNA7HTR3AHTR3EHTR3B | |
| SCHEMBL19981781 | 0.65 | BTK (0.35) | BTKKDM4EALDH1A1LMNAGLA | |
| SCHEMBL395370 | 0.65 | HDAC3 (0.60) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL3262293 | 0.65 | EGFR (0.46) | BTKHTR1ADRD2HTR2A | |
| SCHEMBL3262289 | 0.65 | EGFR (0.46) | BTKHTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |