Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 13/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.38 |
| ▸ | HTR3A | P46098 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268106 | 1.00 | BTK (0.45) | BTKDPP4CHRNA7HTR3AHTR1A | |
| SCHEMBL3260799 | 0.87 | BTK (0.47) | BTKDPP4CHRNA7HTR3AHTR3E | |
| SCHEMBL3262494 | 0.84 | BTK (0.46) | BTKDPP4CHRNA7HTR3AHTR1A | |
| SCHEMBL2490136 | 0.82 | BTK (0.46) | BTKCHRNA7HTR3AHTR1ADRD2 | |
| SCHEMBL2493885 | 0.82 | BTK (0.46) | BTKCHRNA7HTR3AHTR1ADRD2 | |
| SCHEMBL3263368 | 0.76 | DPP4 (0.40) | BTKDPP4 | |
| SCHEMBL3263367 | 0.76 | DPP4 (0.40) | BTKDPP4 | |
| SCHEMBL13303488 | 0.74 | DPP4 (0.54) | DPP4 | |
| SCHEMBL19971540 | 0.74 | BTK (0.40) | BTKCHRNA7HTR3AHTR1ADRD2 | |
| SCHEMBL9984552 | 0.72 | BTK (0.44) | BTKCHRNA7HTR3AHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068806-A1 | AMIDE DERIVATIVES AS BTK INHIBITORS IN THE TREATMENT OF ALLERGIC, AUTOIMMUNE AND INFLAMMATORY DISORDERS AS WELL AS CANCER | CGI PHARMACEUTICALS, INC. (US) | 2010-06-17 | — | — | WO | claimed |