Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 7/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166102 | 1.00 | MBOAT4 (0.48) | MBOAT4HRH3SLC6A4HRH4HTR4 | |
| SCHEMBL16699454 | 0.95 | MBOAT4 (0.52) | MBOAT4HRH3SLC6A4HTR4 | |
| Hydrochloric Acid SCHEMBL16699451 | 0.93 | MBOAT4 (0.51) | MBOAT4HRH3SLC6A4HTR4 | |
| SCHEMBL20009388 | 0.81 | MBOAT4 (0.38) | MBOAT4HRH3SLC6A4 | |
| SCHEMBL16699267 | 0.79 | MBOAT4 (0.39) | MBOAT4HRH3SLC6A4HTR4 | |
| SCHEMBL19979146 | 0.77 | MBOAT4 (0.59) | MBOAT4HRH3HRH4HTR4 | |
| SCHEMBL18166146 | 0.76 | MBOAT4 (0.46) | MBOAT4HRH3SLC6A4HTR4 | |
| SCHEMBL19971822 | 0.74 | MBOAT4 (0.64) | MBOAT4 | |
| SCHEMBL16699213 | 0.72 | MBOAT4 (0.69) | MBOAT4 | |
| SCHEMBL19971808 | 0.71 | MBOAT4 (0.71) | MBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10227310-B2 | Ghrelin 0-acyl transferase inhibitors | ELI LILLY AND COMPANY (US) | 2019-03-12 | — | — | US | disclosed |
| US-20180079729-A1 | GHRELIN 0-ACYL TRANSFERASE INHIBITORS | ELI LILLY AND COMPANY | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10227310-B2 | Ghrelin 0-acyl transferase inhibitors | MBOAT4, GIPR, PLAAT2 | MBOAT4 1/4885HRH3 4291/4885SLC6A4 1039/4885 |
| US-20180079729-A1 | GHRELIN 0-ACYL TRANSFERASE INHIBITORS | MBOAT4, GIPR, PLAAT2 | MBOAT4 1/4885HRH3 4291/4885SLC6A4 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.