Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19972775 | 1.00 | OPRM1 (0.54) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL21294368 | 0.85 | KCNH2 (0.63) | OPRM1OPRD1OPRK1KCNH2MAPK8 | |
| SCHEMBL29484945 | 0.85 | KCNH2 (0.63) | OPRM1OPRD1OPRK1KCNH2MAPK8 | |
| SCHEMBL19972748 | 0.85 | KCNH2 (0.63) | OPRM1OPRD1OPRK1KCNH2MAPK8 | |
| SCHEMBL19972778 | 0.83 | KMT2A (0.50) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL29744520 | 0.83 | KMT2A (0.50) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL19972776 | 0.83 | KMT2A (0.50) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL31037193 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL6368127 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SMYD3KCNH2 | |
| SCHEMBL21739210 | 0.79 | OPRM1 (0.39) | OPRM1OPRD1OPRK1SMYD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512832-A1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | Research Triangle Institute, International (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053222-A1 | TETRAHYDROISOQUINOLINE KAPPA OPIOID ANTAGONISTS | RESEARCH TRAINGLE INSTITUTE (US) | 2018-03-22 | — | — | WO | disclosed |