Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Carisoprodol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 2/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.92 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.92 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.92 |
| ▸ | RAB9A | P51151 | 1/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | CTSK | P43235 | 5/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | CTSH | P09668 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carisoprodol SCHEMBL23856096 | 0.97 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL7565198 | 0.96 | TSHR (0.94) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL2232476 | 0.96 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL158375 | 0.96 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL8379174 | 0.96 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL33286 | 0.96 | TSHR (1.00) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL10448685 | 0.94 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL10713646 | 0.94 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL21633327 | 0.94 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A | |
| Carisoprodol SCHEMBL1646901 | 0.94 | TSHR (0.97) | TSHRLMNACYP3A4NFKB1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053109-A1 | GENE EXPRESSION CHARACTERIZATION OF A GLATIRAMER ACETATE RELATED DRUG PRODUCT IN MAMMALIAN AND HUMAN CELLS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2018-03-22 | — | — | WO | claimed |
| WO-2018053109-A1 | GENE EXPRESSION CHARACTERIZATION OF A GLATIRAMER ACETATE RELATED DRUG PRODUCT IN MAMMALIAN AND HUMAN CELLS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2018-03-22 | — | — | WO | disclosed |