Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CMA1 | P23946 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.54 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.53 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999791 | 0.90 | HTR6 (0.79) | HTR6NPSR1L3MBTL1CMA1HTR2A | |
| SCHEMBL3148370 | 0.89 | HTR6 (1.00) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL1998470 | 0.88 | HTR6 (0.77) | HTR6NPSR1L3MBTL1CMA1HTR2A | |
| SCHEMBL3145090 | 0.88 | HTR6 (1.00) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL3152564 | 0.87 | HTR6 (1.00) | HTR6NPSR1L3MBTL1CMA1HTR2A | |
| SCHEMBL3147604 | 0.87 | HTR6 (1.00) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL3157333 | 0.86 | HTR6 (1.00) | HTR6NPSR1L3MBTL1HTR2AHTR1A | |
| SCHEMBL3147252 | 0.86 | HTR6 (0.90) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL3156507 | 0.85 | HTR6 (0.91) | HTR6NPSR1L3MBTL1CMA1PFKFB3 | |
| SCHEMBL3153770 | 0.84 | HTR6 (1.00) | HTR6NPSR1L3MBTL1HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960568-B2 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-06-14 | — | — | US | disclosed |
| US-7960568-B2 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-06-14 | — | — | US | disclosed |
| US-7960568-B2 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-06-14 | — | — | US | disclosed |
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-03-25 | — | — | US | disclosed |
| WO-2008092665-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-08-07 | — | — | WO | disclosed |
| EP-1953153-A1 | Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders | Laboratorios del Dr. Esteve S.A. (ES) | 2008-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076036-A1 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS | HTR6, HTR2A, HTR2C | HTR6 1/4885NPSR1 25/4885L3MBTL1 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.