Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.47 |
| ▸ | CD63 | P08962 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2479645 | 1.00 | SYK (0.48) | SYKAURKACD63 | |
| SCHEMBL2481645 | 0.85 | SYK (0.50) | SYKAURKA | |
| SCHEMBL2482190 | 0.82 | SYK (0.66) | SYKAURKACD63 | |
| SCHEMBL2524412 | 0.82 | SYK (0.71) | SYKCD63 | |
| SCHEMBL2481735 | 0.82 | AURKA (0.50) | SYKAURKA | |
| SCHEMBL2896223 | 0.80 | SYK (0.65) | SYKAURKACD63 | |
| SCHEMBL12016084 | 0.79 | SYK (0.58) | SYKCD63 | |
| SCHEMBL15301949 | 0.79 | SYK (0.46) | SYKAURKA | |
| SCHEMBL2478946 | 0.78 | SYK (0.64) | SYKCD63 | |
| SCHEMBL13337679 | 0.78 | SYK (0.59) | SYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053189-A2 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2018-03-22 | — | — | WO | disclosed |