Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19973464 | 1.00 | TP53 (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| Hydrochloric Acid SCHEMBL19973960 | 0.99 | MAPT (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| Hydrochloric Acid SCHEMBL19973958 | 0.99 | MAPT (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| SCHEMBL20509562 | 0.89 | TP53 (0.44) | TP53MAPTRAB9ANPC1CYP3A4 | |
| Hydrochloric Acid SCHEMBL19973631 | 0.89 | FADS1 (0.50) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL21189203 | 0.85 | MAPT (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| SCHEMBL19973955 | 0.84 | TP53 (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| SCHEMBL19973882 | 0.84 | TP53 (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| SCHEMBL19973550 | 0.84 | TP53 (0.43) | TP53MAPTRAB9ANPC1CYP3A4 | |
| Hydrochloric Acid SCHEMBL19973578 | 0.83 | TP53 (0.42) | TP53MAPTRAB9ANPC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018052967-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2018-03-22 | — | — | WO | disclosed |