Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.69 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974405 | 1.00 | PTPN1 (0.69) | PTPN1PTPN11KDM4EMAPTPKM | |
| Hydrochloric Acid SCHEMBL7425060 | 0.85 | PTPN1 (0.64) | PTPN1PTPN11KDM4EMAPTALDH1A1 | |
| SCHEMBL13134227 | 0.82 | PTPN1 (1.00) | PTPN1PTPN11KDM4EALDH1A1PLK4 | |
| SCHEMBL7370108 | 0.81 | PTPN1 (0.67) | PTPN1PTPN11KDM4EALDH1A1PLK4 | |
| SCHEMBL9354254 | 0.81 | KDM4E (0.68) | KDM4EMAPTPKMALDH1A1RECQL | |
| SCHEMBL19981586 | 0.80 | LMNA (0.61) | PTPN1PTPN11MAPTPKMALDH1A1 | |
| SCHEMBL27579461 | 0.79 | PLK4 (0.73) | PTPN1PTPN11KDM4EALDH1A1PLK4 | |
| SCHEMBL1902196 | 0.78 | PTPN1 (0.67) | PTPN1PTPN11KDM4EALDH1A1PLK4 | |
| Hydrochloric Acid SCHEMBL7430253 | 0.78 | PTPN1 (0.59) | PTPN1PTPN11KDM4EMAPTALDH1A1 | |
| SCHEMBL11646431 | 0.77 | LPAR2 (0.71) | KDM4EMAPTPKMALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512602-B1 | INHIBITORS OF HEAT SHOCK FACTORS (HSF) AND USES THEREOF | HSF PHARMACEUTICALS (CH) | 2024-03-27 | — | — | EP | disclosed |
| US-11597708-B2 | Inhibitors of heat shock factors and uses thereof | HSF PHARMACEUTICALS SA (CH) | 2023-03-07 | — | — | US | disclosed |
| US-20210221778-A1 | Inhibitors of heat shock factors and uses thereof | HSF PHARMACEUTICALS SA (CH) | 2021-07-22 | — | — | US | disclosed |
| EP-3512602-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF Pharmaceuticals (CH) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018050656-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF PHARMACEUTICALS (CH) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597708-B2 | Inhibitors of heat shock factors and uses thereof | HSF1, HSP90AB2P, HSP90AB1 | PTPN1 4047/4885PTPN11 4069/4885KDM4E 2977/4885 |
| US-20210221778-A1 | Inhibitors of heat shock factors and uses thereof | HSF1, HSP90AB2P, HSP90AB1 | PTPN1 4047/4885PTPN11 4069/4885KDM4E 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.