Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.53 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.53 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.50 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974537 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL23647318 | 0.90 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL19974422 | 0.90 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL19974201 | 0.86 | NMT1 (0.60) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL19974204 | 0.86 | NMT1 (0.60) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL19974429 | 0.85 | ALDH1A1 (0.64) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL23647316 | 0.85 | ALDH1A1 (0.64) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL11753292 | 0.82 | CNR1 (0.54) | ALDH1A1KDM4EKMT2ASMN1; SMN2CNR1 | |
| SCHEMBL19974155 | 0.82 | LPAR2 (0.67) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL19974157 | 0.82 | LPAR2 (0.67) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512602-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF Pharmaceuticals (CH) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018050656-A2 | INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF | HSF PHARMACEUTICALS (CH) | 2018-03-22 | — | — | WO | disclosed |