Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 15/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974621 | 1.00 | YAP1 (0.63) | YAP1GAAPPARGTSHRCYP3A4 | |
| SCHEMBL25922266 | 0.91 | YAP1 (0.58) | YAP1GAAPPARGTSHRCYP3A4 | |
| SCHEMBL19982286 | 0.90 | YAP1 (0.76) | YAP1GAAPPARGTSHR | |
| SCHEMBL19982265 | 0.89 | YAP1 (0.76) | YAP1GAA | |
| SCHEMBL19982204 | 0.87 | YAP1 (0.58) | YAP1GAAPPARG | |
| Hydrochloric Acid SCHEMBL30117583 | 0.87 | YAP1 (0.57) | YAP1GAAPPARG | |
| SCHEMBL19982169 | 0.85 | YAP1 (0.81) | YAP1GAAPPARGTSHR | |
| SCHEMBL19982206 | 0.85 | YAP1 (0.78) | YAP1GAAPPARGTSHR | |
| SCHEMBL23296237 | 0.81 | YAP1 (0.75) | YAP1PPARG | |
| SCHEMBL19982274 | 0.81 | YAP1 (0.75) | YAP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |