Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.69 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974624 | 1.00 | YAP1 (0.69) | YAP1MMP9MMP8POLBGPR34 | |
| SCHEMBL19982070 | 0.90 | YAP1 (0.84) | YAP1MMP9MMP8 | |
| SCHEMBL19976374 | 0.90 | YAP1 (0.71) | YAP1 | |
| SCHEMBL19976373 | 0.90 | YAP1 (0.71) | YAP1 | |
| SCHEMBL19982062 | 0.90 | YAP1 (0.86) | YAP1MMP9MMP8 | |
| SCHEMBL19975554 | 0.89 | YAP1 (0.70) | YAP1GPR34 | |
| SCHEMBL19975552 | 0.89 | YAP1 (0.70) | YAP1GPR34 | |
| SCHEMBL19975509 | 0.88 | YAP1 (0.83) | YAP1 | |
| SCHEMBL19975511 | 0.88 | YAP1 (0.83) | YAP1 | |
| SCHEMBL19975444 | 0.88 | YAP1 (0.79) | YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |