SCHEMBL19974948

SCHEMBL19974948

COC(=O)C(C)N(C=O)Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
CHRNB2 P17787 1/20 0.45
CHRNB4 P30926 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA4 P43681 1/20 0.45
MAPT P10636 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
EPOR P19235 1/20 0.44
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
ANPEP P15144 1/20 0.42
PTGES O14684 1/20 0.42
MMP1 P03956 1/20 0.42
MMP3 P08254 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ALDH1A1 P00352 1/20 0.42
THRB P10828 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19974876 0.84 MEN1 (0.47) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL7284391 0.84 KMT2A (0.51) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL21563181 0.82 EPOR (0.45) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL21183516 0.81 HPGD (0.46) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL12492396 0.81 KMT2A (0.56) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL5655931 0.81 KMT2A (0.56) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL5655937 0.81 KMT2A (0.56) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL19975230 0.80 MEN1 (0.40) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL19203449 0.80 KMT2A (0.56) KMT2AMEN1CHRNB2CHRNB4CHRNA3
SCHEMBL27783385 0.80 KMT2A (0.56) KMT2AMEN1CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220356148-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2022-11-10 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
US-11091428-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-08-17 US disclosed
WO-2019215203-A1 TETRACYCLIC HETEROARYL COMPOUNDS ASTRAZENECA AB (SE) 2019-11-14 WO disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
US-20190225575-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2019-07-25 US disclosed
EP-3512836-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2019-07-24 EP disclosed
WO-2018050631-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2018-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190225575-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G12A, PLA2G4C KMT2A 4031/4885MEN1 4331/4885CHRNB2 4396/4885
US-20220356148-A1 ANTIVIRAL COMPOUNDS PLA2G12A, PLA2G1B, PLA2G4C KMT2A 4177/4885MEN1 4361/4885CHRNB2 4389/4885
US-11091428-B2 Antiviral compounds PLA2G1B, PLA2G12A, PLA2G4C KMT2A 4031/4885MEN1 4331/4885CHRNB2 4396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.