Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.75 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982137 | 0.92 | YAP1 (0.78) | YAP1PPARG | |
| SCHEMBL19982250 | 0.92 | YAP1 (0.78) | YAP1PPARG | |
| SCHEMBL19975559 | 0.88 | YAP1 (0.79) | YAP1GPR34POLBPPARG | |
| SCHEMBL23296240 | 0.87 | YAP1 (0.85) | YAP1GPR34POLB | |
| SCHEMBL22929160 | 0.87 | YAP1 (0.85) | YAP1GPR34POLB | |
| SCHEMBL19974549 | 0.87 | YAP1 (0.85) | YAP1GPR34POLB | |
| SCHEMBL19974550 | 0.85 | YAP1 (0.81) | YAP1GPR34POLBPPARG | |
| SCHEMBL19982108 | 0.85 | YAP1 (1.00) | YAP1GPR34POLB | |
| SCHEMBL23296225 | 0.85 | YAP1 (1.00) | YAP1GPR34POLB | |
| SCHEMBL19974592 | 0.85 | YAP1 (1.00) | YAP1GPR34POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |