Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.60 |
| ▸ | JAK3 | P52333 | 13/20 | 0.60 |
| ▸ | JAK2 | O60674 | 11/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | BRD4 | O60885 | 6/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609671 | 0.90 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL524757 | 0.90 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL525125 | 0.89 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL341026 | 0.89 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| Calcium SCHEMBL29358619 | 0.89 | JAK1 (0.59) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL17236302 | 0.89 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL10177169 | 0.88 | JAK1 (0.46) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL2990449 | 0.88 | JAK1 (0.61) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL10177144 | 0.87 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 | |
| SCHEMBL29358675 | 0.87 | JAK1 (0.60) | JAK1JAK3JAK2CYP1A2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162848-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-9920041-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2018-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162848-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | JAK1 3/4885JAK3 1/4885JAK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.