Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | SMO | Q99835 | 1/20 | 0.67 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.66 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.66 |
| ▸ | PPARG | P37231 | 1/20 | 0.65 |
| ▸ | PPARA | Q07869 | 1/20 | 0.65 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ACLY | P53396 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8278418 | 0.89 | NPC1 (0.71) | NPC1RAB9AMAPTSMOKCNK3 | |
| SCHEMBL2495198 | 0.88 | KCNK3 (0.67) | NPC1RAB9AMAPTKCNK3KCNK9 | |
| SCHEMBL23707818 | 0.86 | NR1H4 (0.61) | NPC1RAB9AMAPTSMOKCNK3 | |
| SCHEMBL2493233 | 0.86 | KCNK3 (0.68) | NPC1RAB9AKCNK3KCNK9PPARG | |
| SCHEMBL2494059 | 0.86 | CSF1R (0.67) | NPC1RAB9AMAPTKCNK3KCNK9 | |
| SCHEMBL11593167 | 0.85 | KMT2A (0.76) | NPC1RAB9AMAPTKCNK3KCNK9 | |
| SCHEMBL30369807 | 0.85 | NPC1 (1.00) | NPC1RAB9AMAPTSMOKCNK3 | |
| SCHEMBL4254257 | 0.85 | NPC1 (1.00) | NPC1RAB9AMAPTSMOKCNK3 | |
| SCHEMBL2498414 | 0.84 | RAB9A (0.76) | NPC1RAB9AKCNK3KMT2AMEN1 | |
| SCHEMBL2494946 | 0.84 | PPARG (0.62) | NPC1RAB9AMAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1051036-A | The treatment of HIV (human immunodeficiency virus) infections and in treatment used compound | UNIROYAL CHEM CO INC (US) | 1991-05-01 | — | — | CN | claimed |
| US-9926276-B2 | Substituted benzamides with activity towards EP4 receptors | DRACONIS PHARMA, S.L. (ES) | 2018-03-27 | — | — | US | disclosed |