Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976812 | 0.91 | GSK3B (0.51) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976817 | 0.90 | GSK3B (0.53) | GSK3BHDAC6MAPK1MAP2K4HDAC1 | |
| SCHEMBL19976907 | 0.90 | GSK3B (0.49) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976882 | 0.89 | MAPK1 (0.46) | GSK3BHDAC6MAPK1MAP2K4MAPK6 | |
| SCHEMBL19976828 | 0.87 | GSK3B (0.49) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976753 | 0.87 | GSK3B (0.47) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976815 | 0.85 | GSK3B (0.44) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976764 | 0.85 | GSK3B (0.48) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976733 | 0.82 | HDAC6 (0.47) | GSK3BTRPA1HDAC6MAPK1MAP2K4 | |
| SCHEMBL19976858 | 0.80 | MAPK1 (0.46) | GSK3BHDAC6MAPK1MAP2K4MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |