Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.39 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.39 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976812 | 0.94 | GSK3B (0.51) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976828 | 0.91 | GSK3B (0.49) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976731 | 0.88 | MAPK1 (0.42) | GSK3BMAPK1HDAC6NTRK1MAPK8 | |
| SCHEMBL19976800 | 0.88 | GSK3B (0.43) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976907 | 0.87 | GSK3B (0.49) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976858 | 0.86 | MAPK1 (0.46) | GSK3BMAPK1HDAC6MAP2K4MAPK6 | |
| SCHEMBL19976763 | 0.85 | GSK3B (0.52) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976764 | 0.85 | GSK3B (0.48) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976854 | 0.85 | GSK3B (0.42) | GSK3BTRPA1MAPK1HDAC6MAP2K4 | |
| SCHEMBL19976753 | 0.84 | GSK3B (0.47) | GSK3BTRPA1MAPK1HDAC6MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |