Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976756 | 0.91 | MAPT (0.46) | MAPTSTAT3SMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL19976814 | 0.88 | MAPT (0.47) | MAPTSTAT3SMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL19976816 | 0.85 | MAPT (0.46) | MAPTSTAT3SMN1; SMN2GSK3BMAPK1 | |
| SCHEMBL19976767 | 0.80 | GSK3B (0.51) | MAPTGSK3BMAPK1HDAC6 | |
| SCHEMBL16771465 | 0.79 | MAPT (0.45) | MAPTSTAT3SMN1; SMN2DGAT1SOAT1 | |
| SCHEMBL19976729 | 0.78 | HDAC6 (0.49) | GSK3BMAPK1HDAC6 | |
| SCHEMBL19976796 | 0.75 | MAPT (0.43) | MAPTSTAT3SMN1; SMN2MAPK1DGAT1 | |
| SCHEMBL19976854 | 0.74 | GSK3B (0.42) | MAPTGSK3BMAPK1KCNH2HDAC6 | |
| SCHEMBL19976745 | 0.71 | GSK3B (0.45) | GSK3BMAPK1FGFR1HDAC6 | |
| SCHEMBL17089509 | 0.70 | HDAC10 (0.40) | MAPTSTAT3SMN1; SMN2MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |