Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 4/20 | 0.37 |
| ▸ | BRAF | P15056 | 4/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976928 | 0.82 | CTNNB1 (0.37) | MAPK1ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL19976944 | 0.81 | MAPK1 (0.36) | MAPTSMN1; SMN2MAPK1ALDH1A1KDM4E | |
| SCHEMBL19976798 | 0.79 | PTGES (0.36) | MAPTMAPK1ALDH1A1GAAKDM4E | |
| SCHEMBL19976851 | 0.75 | POLB (0.35) | MAPTSMN1; SMN2MAPK1ALDH1A1KDM4E | |
| SCHEMBL19976845 | 0.75 | MAPT (0.45) | MAPTSTAT3SMN1; SMN2MAPK1RAF1 | |
| SCHEMBL19976814 | 0.73 | MAPT (0.47) | MAPTSTAT3SMN1; SMN2MAPK1DGAT1 | |
| SCHEMBL19976756 | 0.73 | MAPT (0.46) | MAPTSTAT3SMN1; SMN2MAPK1DGAT1 | |
| SCHEMBL19976833 | 0.73 | HPGD (0.41) | MAPTSMN1; SMN2MAPK1ALDH1A1GAA | |
| SCHEMBL19976727 | 0.73 | GSK3B (0.36) | MAPTMAPK1 | |
| SCHEMBL19976770 | 0.72 | MAPK1 (0.38) | MAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |