Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953115 | 0.77 | MAPT (0.48) | LMNAALDH1A1HPGDRAB9ACYP1A2 | |
| SCHEMBL23088455 | 0.77 | TUBB1 (0.41) | TUBB1HTR2AHTR2CHTR2BNFE2L2 | |
| SCHEMBL953686 | 0.77 | ERN1 (0.44) | TUBB1LMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL953115 | 0.76 | EZH2 (0.36) | TUBB1AMY1AHTR2AHTR2CHTR2B | |
| SCHEMBL17221496 | 0.72 | KDM4E (0.56) | TUBB1AMY1ANFE2L2LMNAALDH1A1 | |
| SCHEMBL17221495 | 0.72 | KDM4E (0.56) | TUBB1AMY1ANFE2L2LMNAALDH1A1 | |
| SCHEMBL802723 | 0.71 | HTR2A (0.44) | TUBB1HTR2AHTR2CHTR2BNFE2L2 | |
| SCHEMBL15682035 | 0.70 | CA2 (0.47) | TUBB1NFE2L2LMNAALDH1A1KDM4E | |
| SCHEMBL6739214 | 0.69 | KDM4E (0.53) | TUBB1AMY1AHTR2AHTR2CHTR2B | |
| SCHEMBL6739211 | 0.69 | KDM4E (0.53) | TUBB1AMY1AHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |