⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19661047 | 0.82 | — | — | |
| SCHEMBL14043649 | 0.73 | — | — | |
| SCHEMBL13844882 | 0.71 | — | — | |
| SCHEMBL13926008 | 0.69 | — | — | |
| SCHEMBL14996695 | 0.69 | — | — | |
| SCHEMBL15764321 | 0.69 | — | — | |
| SCHEMBL18855272 | 0.69 | — | — | |
| SCHEMBL14339632 | 0.69 | — | — | |
| SCHEMBL13679279 | 0.69 | — | — | |
| SCHEMBL21973918 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024031002-A1 | (2,4-DICHLOROPHENOXY)ACETIC ACID ANALOGS | CORTEVA AGRISCIENCE LLC (US) | 2024-02-08 | — | — | WO | disclosed |
| US-11180497-B2 | Cyclic compounds as immunomodulating agents | ANGEX PHARMACEUTICAL, INC. (US) | 2021-11-23 | — | — | US | disclosed |
| US-10946013-B2 | Methods for treating central nervous system disorders using vdac inhibitors | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2021-03-16 | — | — | US | disclosed |
| US-20200276180-A1 | POLYCYCLIC COMPOUND ACTING AS IDO INHIBITOR AND/OR IDO-HDAC DUAL INHIBITOR | HANGZHOU INNOGATE PHARMA CO., LTD (CN) | 2020-09-03 | — | — | US | disclosed |
| US-20200239464-A1 | CYCLIC COMPOUNDS AS IMMUNOMODULATING AGENTS | ANGEX PHARMACEUTICAL, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10508091-B2 | Piperazine and piperidine derivatives, their synthesis and use thereof in inhibiting VDAC oligomerization, apoptosis and mitochondria dysfunction | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2019-12-17 | — | — | US | disclosed |
| US-10434099-B2 | Methods for treating central nervous system disorders using VDAC inhibitors | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2019-10-08 | — | — | US | disclosed |
| US-20180118700-A1 | NOVEL PIPERAZINE AND PIPERIDINE DERIVATIVES, THEIR SYNTHESIS AND USE THEREOF IN INHIBITING VDAC OLIGOMERIZATION, APOPTOSIS AND MITOCHONDRIA DYSFUNCTION | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2018-05-03 | — | — | US | disclosed |
| US-20180078548-A1 | Methods for Treating Central Nervous System Disorders Using VDAC Inhibitors | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2018-03-22 | — | — | US | disclosed |