Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19978970 | 0.92 | P2RX3 (0.56) | P2RX3ADORA3ALDH1A1LMNAALB | |
| SCHEMBL22700214 | 0.85 | HPGD (0.49) | IMPDH2IMPDH1ADORA2ANT5E | |
| SCHEMBL19974568 | 0.85 | ADORA2A (0.55) | P2RX3ALDH1A1ADORA2ANT5E | |
| SCHEMBL19979029 | 0.81 | ADORA2A (0.57) | ADORA3LMNAADORA2ANT5E | |
| SCHEMBL19974418 | 0.81 | ADORA2A (0.57) | ADORA3LMNAADORA2ANT5E | |
| SCHEMBL19974575 | 0.79 | ADORA2A (0.43) | ADORA3ADORA2ANT5E | |
| SCHEMBL15045893 | 0.75 | ADORA2A (0.52) | P2RX3ADORA3ALDH1A1LMNAALB | |
| SCHEMBL13559257 | 0.73 | ADORA2A (0.66) | P2RX3ADORA3ALDH1A1LMNAALB | |
| SCHEMBL12149438 | 0.73 | ADORA2A (0.66) | P2RX3ADORA3ALDH1A1LMNAALB | |
| SCHEMBL13559231 | 0.73 | ADORA2A (0.66) | P2RX3ADORA3ALDH1A1LMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512860-B1 | NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT | LCB PHARMA INC (CA) | 2020-11-25 | — | — | EP | disclosed |
| WO-2018049534-A1 | NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT | LCB PHARMA INC. (CA) | 2018-03-22 | — | — | WO | disclosed |