Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 6/20 | 0.62 |
| ▸ | PPP5C | P53041 | 2/20 | 0.62 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.62 |
| ▸ | NPY4R | P50391 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | PPM1B | O75688 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12390213 | 0.94 | TFPI2 (0.70) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| SCHEMBL9880159 | 0.94 | TFPI2 (0.70) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| SCHEMBL26377804 | 0.94 | TFPI2 (0.70) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| SCHEMBL9880175 | 0.84 | TFPI2 (0.59) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| SCHEMBL26377916 | 0.78 | PPM1B (0.55) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| Lb-100 SCHEMBL9880148 | 0.77 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| Lb-100 SCHEMBL13311584 | 0.77 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| Lb-100 SCHEMBL19512780 | 0.77 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| Lb-100 SCHEMBL12390164 | 0.77 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RTSHR | |
| Lb-100 SCHEMBL26377801 | 0.77 | TFPI2 (1.00) | TFPI2PPP5CPPP2CANPY4RTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870161-B1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF REPERFUSION INJURY | LIXTE BIOTECHNOLOGY INC (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-2714924-B1 | HDAC Inhibitors for use in the treatment of Gaucher's disease, von Hippel-Lindau disease, phaeochromocytoma and paragangliomas. | LIXTE BIOTECHNOLOGY INC (US) | 2018-03-21 | — | — | EP | disclosed |