Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TFPI2 | P48307 | 6/20 | 0.59 |
| ▸ | PPM1B | O75688 | 2/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.58 |
| ▸ | PPP1CC | P36873 | 2/20 | 0.58 |
| ▸ | PPP5C | P53041 | 2/20 | 0.51 |
| ▸ | PPP2CA | P67775 | 1/20 | 0.51 |
| ▸ | NPY4R | P50391 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9880159 | 0.86 | TFPI2 (0.70) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL12390213 | 0.86 | TFPI2 (0.70) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL26377804 | 0.86 | TFPI2 (0.70) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL26377916 | 0.85 | PPM1B (0.55) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL19979625 | 0.84 | TFPI2 (0.62) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL8080046 | 0.81 | PPM1B (0.84) | TFPI2PPM1BPTPN1PPP1CCTSHR | |
| SCHEMBL9880174 | 0.80 | TFPI2 (0.90) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL18073223 | 0.80 | TFPI2 (0.90) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL13311562 | 0.80 | TFPI2 (0.90) | TFPI2PPM1BPTPN1PPP1CCPPP5C | |
| SCHEMBL12122108 | 0.79 | TFPI2 (0.65) | TFPI2PPP5CPPP2CANPY4RSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9833450-B2 | Oxabicycloheptanes and oxabicycloheptenes for the treatment of depressive and stress disorders | LIXTE BIOTECHNOLOGY, INC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20170340628-A1 | PROTEIN PHOSPHATASE 2A INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROMES | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170259081-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | LIXTE BIOTECHNOLOGY, INC. (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170209434-A1 | PROTEIN PHOSPHATASE 2A INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROMES | H LEE MOFFITT CANCER CT & RES (US) | 2017-07-27 | — | — | US | disclosed |
| US-20170136008-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF OVARIAN CANCER | LIXTE BIOTECHNOLOGY, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-9526915-B2 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphatase | LIXTE BIOTECHNOLOGY, INC. | 2016-12-27 | — | — | US | disclosed |
| US-20160303115-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DEPRESSIVE AND STRESS DISORDERS | LIXTE BIOTECHNOLOGY, INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-20160074390-A1 | HUMAN DOSING OF PHOSPHATASE INHIBITOR | LIXTE BIOTECHNOLOGY, INC. (US) | 2016-03-17 | — | — | US | disclosed |
| US-9079917-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2015-07-14 | — | — | US | disclosed |
| US-20150174123-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF REPERFUSION INJURY | LIXTE BIOTECHNOLOGY, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| US-20150045373-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE | LIXTE BIOTECHNOLOGY, INC. | 2015-02-12 | — | — | US | disclosed |
| US-8822461-B2 | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140235649-A1 | USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION | LIXTE BIOTECHNOLOGY, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-20130302402-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE | LIXTE BIOTECHNOLOGY, INC. (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130280210-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | LIXTE BIOTECHNOLOGY, INC. | 2013-10-24 | — | — | US | disclosed |
| US-20120135522-A1 | METHODS OF MODULATING CELL REGULATION BY INHIBITING P53 | LIXTE BIOTECHNOLOGY, INC. | 2012-05-31 | — | — | US | disclosed |
| US-8058268-B2 | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases | LIXTE BIOTECHNOLOGY, INC. (US) | 2011-11-15 | — | — | US | disclosed |
| US-7998957-B2 | Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | LIXTE BIOTECHNOLOGY, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20090036309-A1 | Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use | LIXTE BIOTECHNOLOGY, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160074390-A1 | HUMAN DOSING OF PHOSPHATASE INHIBITOR | PPM1A, PPP2R2A, PPM1B | TFPI2 2148/4885PPM1B 3/4885PTPN1 59/4885 |
| US-20100029683-A1 | Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses | PSPH, PPP5C, BUB1B | TFPI2 2409/4885PPM1B 184/4885PTPN1 1382/4885 |
| US-20140235649-A1 | USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION | HDAC1, PPP3CA, PPM1A | TFPI2 1154/4885PPM1B 17/4885PTPN1 504/4885 |
| US-20170136008-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF OVARIAN CANCER | OAT, OGG1, OTC | TFPI2 4233/4885PPM1B 1919/4885PTPN1 2495/4885 |
| US-20150045373-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE | HCCS, OXA1L, OTC | TFPI2 4858/4885PPM1B 3573/4885PTPN1 3699/4885 |
| US-20130302402-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES, THEIR PREPARATION AND USE | HCCS, OXA1L, OTC | TFPI2 4858/4885PPM1B 3573/4885PTPN1 3699/4885 |
| US-20130280210-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | PPP5C, BUB1B, CDC25C | TFPI2 2737/4885PPM1B 149/4885PTPN1 1061/4885 |
| US-20090036309-A1 | Oxabicycloheptanes and oxabicylcoheptenes, their preparation and use | HCCS, VHL, OXA1L | TFPI2 4843/4885PPM1B 3454/4885PTPN1 3848/4885 |
| US-20170340628-A1 | PROTEIN PHOSPHATASE 2A INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROMES | PPP2CA, PPP2R2A, PPP3CA | TFPI2 912/4885PPM1B 10/4885PTPN1 207/4885 |
| US-20170209434-A1 | PROTEIN PHOSPHATASE 2A INHIBITORS FOR TREATING MYELODYSPLASTIC SYNDROMES | PPP2CA, PPP2R2A, PPM1A | TFPI2 1195/4885PPM1B 7/4885PTPN1 175/4885 |
| US-20150174123-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF REPERFUSION INJURY | PPP2CA, PPP4C, PPP3CA | TFPI2 1253/4885PPM1B 21/4885PTPN1 114/4885 |
| US-20160303115-A1 | OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF DEPRESSIVE AND STRESS DISORDERS | HSD17B11, HSD17B1, CRH | TFPI2 4289/4885PPM1B 1974/4885PTPN1 3383/4885 |
| US-20170259081-A1 | METHODS FOR REGULATING CELL MITOSIS BY INHIBITING SERINE/THREONINE PHOSPHATASE | PPP5C, BUB1B, CDC25C | TFPI2 2737/4885PPM1B 149/4885PTPN1 1061/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.